Two Step Laser Mass Spectrometry
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Compact two-step laser time-of-flight mass spectrometer for in situ analyses of aromatic organics on planetary missions.
RATIONALE A miniature time-of-flight mass spectrometer measuring 20 cm in length has been adapted to demonstrate two-step laser desorption/ionization (LDI) in a compact instrument package for enhanced organics detection. Two-step LDI decouples the desorption and ionization processes, relative to traditional LDI, in order to produce low-fragmentation mass spectra of organic analytes. Tuning the ...
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Introduction: Amajor problem in the treatment of cancer is the lack of an appropriate method for the early diagnosis of the disease. The chemical reaction within an organ may be reflected in the form of proteomic patterns in the serum, sputum, or urine. Laser mass spectrometry is a valuable tool for extracting the proteomic patterns from biological samples. A major challenge in extracting such ...
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We have developed a mlcroanalytlcal Instrument to analyze the organk constltuonts of partlculates and Inhomogeneous samples wtth aspaUal ramlutbn ol approxlmatdy 40 pm. Om method, two-step laser desorptlon/laser lonlzatlon mass spectrometry (L2MS), uses an Infrared laser to volatlllze constttuent mokuks Intact and an ultraviolet l a w to lonlze desorbed molecules In a selective manner with Imle...
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The conversion or photo conversion of asphaltenes to polycyclic aromatic hydrocarbons (PAH’s) promoted by a laser source is analyzed using both experimental and theoretical methods. We propose that during measurements performed at an intermediate laser power, fragmentation to afford PAH’s and ring fusion to yield fused PAH’s (FPAH’s) may occur either within molecular clusters (resin case) or wi...
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A mass spectrometric method is described for the rapid mapping of linear epitopes in proteins that are bound by monoclonal antibodies. The method consists of three steps. In the first step, an antigen protein is digested by a proteolytic enzyme to produce an appropriate set of peptide fragments. In the second step, peptide fragments containing the linear epitope are selected and separated from ...
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تاریخ انتشار 2001